Medicinal Chemistry

EBook Description: Many of us think nothing of taking a painkiller to ease a headache, or to relieve the symptoms of 'flu. But how do drugs have their effect in the human body? How are new drugs discovered and designed to be as effective as possible? An Introduction to Medicinal Chemistry offers an engaging insight into the one field of chemistry that arguably has the greatest impact on our quality of life than any other. Newly structured into four parts, the book opens in Part A with an introduction to pharmacodynamics and pharmacokinetics. Pharmacodynamics considers the types of molecular targets used by drugs, the interactions which are involved when a drug meets that target, and the consequences of those interactions. Pharmacokinetics considers the issues involved in a drug reaching its target in the first place. Part B goes on to examine the general principles and strategies involved in discovering and designing new drugs and developing them for the marketplace, while Part C looks at particular 'tools of the trade' which are invaluable in those processes. Finally, Part D covers a selection of specific topics within medicinal chemistry. Reflecting a change in emphasis in medicinal chemistry research, this Part takes us from the largely trial-and-error approach to drug design to the rational approach, and explores the most recent advances in molecular biology and genetics which have revolutionised drug design. With a striking new two-colour text design, and greatly enriched learning features, the third edition conveys the fascination of working in a field which overlaps the disciplines of chemistry, biochemistry, physiology, microbiology, cell biology, and pharmacology. A must-have textbook for any student of medicinal chemistry. Online Resource Centre - Figures available to download, to facilitate lecture preparation - 3D molecular structures, to enable students to visualise key structures in an interactive way - Multiple choice questions with answers, to support and encourage independent learning

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Organobismuth Chemistry

This book is written for scientists who require information on organobismuth chemistry, either by specific topic or by compound. "Organobismuth Chemistry" covers, through early 1999, stoichiometric compounds that contain the Bi-C bond; not included, with the exception of a few examples, are inorganic compounds, minerals, metal alloys, and non-stoichiometric materials.

The Biological Chemistry of the Elements: The Inorganic Chemistry of Life

Twenty inorganic elements, mostly metal ions, are consistently found in living systems and are essential for living systems to function correctly. This text discusses, describes and explains the functional relevance of those elements: the reasons for their selection; the processes of their uptake; transport and final localization in cells; the regulation of these processes; and the interactive network of their reactions that connects the in vivo inorganic elements to the environment and to the genome. The volume has been thoroughly revised for this second edition and includes a discussion of the link to the genome of the uptake and transfer of inorganic elements and the regulation of homeostasis, the functional co-operative activities of the elements, the interaction with the environment, and the evolution of usage. Recent structural and mechanistic knowledge of many biomolecules and organelles is also included.

Reviews in Computational Chemistry

Succeed in your course with the help of this proven best-seller! John McMurry's Organic Chemistry is consistently praised as the most clearly written book available for the course. In John McMurry's words: "I wrote this book because I love writing. I get great pleasure and satisfaction from taking a complicated subject, turning it around until I see it clearly from a new angle, and then explaining it in simple words." Through his lucid writing and ability to show the beauty and logic of organic chemistry, McMurry makes learning enjoyable. The highest compliment that can be given to a chemistry book applies to McMurry: It works!

Chemistry

CHEMISTRY outlines chemistry basics using a thoughtful approach built on problem solving. The book speaks directly to the reader about how to approach and solve chemical problems?to learn to think like a chemist?so that they can apply the process of problem-solving to all aspects of their lives.

Organic Chemistry

The text continues to build on its reputation of providing students with a progressive introduction to organic chemistry. One of the most outstanding features of the new edition is an increased and more thorough coverage of mechanisms. ORGANIC CHEMISTRY, Third edition is clearly written and provides students with many more real life examples of organic chemistry, especially in the areas of bio-organic chemistry and medicinal chemistry.

Essential Cell Biology

Essential Cell Biology, Second Edition contains basic, core knowledge about how cells work. It has a proven track record in providing students with a conceptual and accessible grounding in cell biology. The text and figures have been prepared to be easy-to-follow, accurate, clear and engaging for the introductory student. Each section follows logically from the previous one, telling a story, rather than being a collection of facts. Questions integrated throughout each chapter encourage the reader to pause, think about what they have read, and attempt to apply the new knowledge in ways that test their understanding. Based on user feedback, the Second Edition now offers increased coverage of genetics and more experimental background.

Human Biology

This market leading human biology text emphasizes the relationships of humans to other living things. "Human Biology" remains user friendly; relevancy and pedagogy are among its strengths. In this edition, as in previous editions, each chapter presents the topic clearly and distinctly so that students will feel capable of achieving an adult level of understanding. Detailed, high-level scientific data and terminology are not included. --This text refers to an out of print or unavailable edition of this title.

Molecular Cell Biology

Molecular Cell Biology stands out from its peers in this course in that it provides a clear introduction to the techniques and experiments of scientists past and present, not just an “encyclopedia” of information. This experimental emphasis, together with a solid pedagogical framework in the chapters, provides the clearest, most cutting-edge text available.

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